AC-(D)PHE-PRO-BOROHOMOORNITHINE-OH

AC-(D)PHE-PRO-BOROHOMOORNITHINE-OH is a synthetic small molecule peptidomimetic, classified as a dipeptide derivative containing a borohomoornithine residue. It is an experimental compound primarily used as a discovery agent in research settings. Structurally, it features an acetylated D‑phenylalanine and proline sequence with a boron-containing ornithine analog at the C-terminal. This compound is related to other peptide-based inhibitors of serine proteases such as thrombin, and similar molecules have been shown to act as potent competitive inhibitors of thrombin by mimicking substrate recognition motifs[3][4]. Its mechanism likely involves covalent or tight binding to the active site serine of target proteases via its boronic acid moiety, which forms reversible covalent bonds with catalytic residues.

Other names

N-acetyl-D-phenylalanyl-N-[(1R)-4-amino-1-(dihydroxyboranyl)butyl]-L-prolinamide(1R)-4-amino-1-{[(2S)-1-[(2R)-2-acetamido-3-phenylpropanoyl]pyrrolidin-2-yl]formamido}butylboronic acid[(1R)-1-[[(2S)-1-[(2R)-2-acetamido-3-phenylpropanoyl]pyrrolidine‑2‑carbonyl]amino]-4‑aminobutyl]boronic acid