AC-(D)Phe-pro-borolys-OH

AC-(D)Phe-pro-borolys-OH is an experimental small molecule dipeptide containing a boronic acid moiety. It acts as a potent, covalent inhibitor of prothrombin (also known as coagulation factor II), specifically targeting the active site of the enzyme. The compound has been structurally characterized in complex with human alpha-thrombin, indicating its mechanism involves direct inhibition of thrombin activity by binding to its catalytic site. This mechanism suggests potential utility as an anticoagulant or antithrombotic agent, though it has not advanced beyond preclinical or early experimental stages and is not approved for any indication[1][6][10].

Other names

((1R)-5-amino-1-(((2S)-1-((2R)-2-acetamido-3-phenylpropanoyl)pyrrolidin-2-yl)formamido)pentyl)boronic acid[(1R)-5-amino-1-{[(2S)-1-[(2R)-2-acetamido-3-phenylpropanoyl]pyrrolidin-2‑yl]formamido}pentyl]boronic acid