aceclofenac + acetaminophen

Aceclofenac + acetaminophen (also known as aceclofenac and paracetamol) is an approved oral small molecule combination drug. It combines aceclofenac, a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID), with acetaminophen (paracetamol), a widely used analgesic and antipyretic. Aceclofenac primarily targets and inhibits the cyclooxygenase enzymes COX-1 and COX-2, thereby reducing the production of prostaglandins that mediate pain, swelling, and inflammation. Acetaminophen complements this action through its own analgesic and antipyretic mechanisms, likely involving central COX inhibition and modulation of pain pathways. The combination is indicated for the treatment of pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, musculoskeletal disorders, and dental pain. It is manufactured as a generic formulation by companies including CRIS Pharma.

Other names

aceclofenac + paracetamolaceclofenac and paracetamol tablets