Aceclofenac + Esomeprazole

Aceclofenac + esomeprazole is a fixed-dose combination of two active pharmaceutical ingredients: - **Aceclofenac** is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. It is primarily used to treat conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute pain[5][8]. - **Esomeprazole** is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by irreversibly binding to the H+, K+-ATPase enzyme in gastric parietal cells. This action reduces both basal and stimulated acid production[6]. The combination aims to provide effective pain relief while minimizing gastrointestinal side effects commonly associated with NSAIDs by including a PPI for gastroprotection[3][8]. The formulation improves patient convenience and adherence by combining both agents into one dosage form.

Brand names

Aclon-E

Other names

Aceclofenac/Esomeprazole Dong WhaAclon EDW-6008DW6008DW 6008