Drug intelligence / Profile preview

aceclofenac + paracetamol (Mandevis Pharma)

Development stage
Unknown
Lead developer
Mandevis Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Jaidol-P is a fixed-dose combination analgesic and anti-inflammatory medication containing aceclofenac and paracetamol. Aceclofenac is a phenylacetic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the cyclooxygenase (COX) enzymes, thereby reducing the synthesis of inflammatory prostaglandins. Paracetamol, also known as acetaminophen, serves as an analgesic and antipyretic agent, likely exerting its effects through the inhibition of prostaglandin synthesis in the central nervous system and modulation of the endocannabinoid system. This combination is marketed by Mandevis Pharma for the management of pain and inflammation associated with musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

Brand names
Jaidol-P
Other names
Aceclofenac and Paracetamol
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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