acetaminophen + caffeine

Acetaminophen + Caffeine (also known as paracetamol with caffeine) is an approved oral small molecule combination drug used for the relief of mild to moderate pain. The combination consists of **acetaminophen**, a non-opioid analgesic and antipyretic, and **caffeine**, a methylxanthine that acts as a central nervous system stimulant and analgesic adjuvant. Acetaminophen primarily works by inhibiting prostaglandin synthesis in the central nervous system, thereby reducing pain and fever. Caffeine acts as an adenosine receptor antagonist; in this combination, it enhances the analgesic efficacy of acetaminophen and may accelerate its onset of action by modulating pain perception and improving drug absorption. It is commonly indicated for conditions such as tension headaches, migraines, musculoskeletal pain, and general aches.

Brand names

Panadol ExtraSolpadeine HeadacheHedex ExtraExcedrin Tension Headache

Other names

paracetamol + caffeineacetaminophen and caffeineParacetamol with Caffeine Tablets