acetaminophen + codeine + doxylamine

**Acetaminophen + codeine + doxylamine** is a combination pharmaceutical drug used for relief of mild to moderate pain often associated with tension, headache, migraines, dental pain, muscle pain, nerve pain, period pain, or flu symptoms[1][9][10]. - **Acetaminophen** acts as an analgesic and antipyretic, reducing pain and fever. Its mechanism is believed to involve inhibition of prostaglandin synthesis in the central nervous system. - **Codeine** is an opioid analgesic that works by activating mu-opioid receptors in the central nervous system, inhibiting transmission of pain signals[7]. - **Doxylamine** is a first-generation antihistamine with pronounced sedative effects, acting as an antagonist at histamine H1 receptors to relieve symptoms of allergy and enhance the calmative effects of the combination[1][9]. Combined, these agents provide synergistic analgesia and sedation, suitable for situations needing both pain relief and calmative effects. This combination is marketed under several brand names, with formulations typically consisting of acetaminophen 325 mg, codeine phosphate 8 mg, and doxylamine succinate 5 mg per tablet[1][9].

Brand names

MersyndolAPOHEALTH Paracetamol Plus Codeine and Calmative

Other names

acetaminophen + codeine phosphate + doxylamine succinateparacetamol + codeine + doxylamine succinate