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acetaminophen + dextromethorphan + phenylephrine
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Acetaminophen + dextromethorphan + phenylephrine is an over-the-counter combination medication used for the symptomatic relief of cold and flu symptoms, including headache, fever, body aches, cough, stuffy nose, and sinus congestion. Acetaminophen acts as a pain reliever (analgesic) and fever reducer (antipyretic) by inhibiting prostaglandin synthesis in the central nervous system. Dextromethorphan is a cough suppressant that works on the brain's cough center to reduce the urge to cough. Phenylephrine is a nasal decongestant that acts as an alpha-1 adrenergic receptor agonist causing vasoconstriction in nasal blood vessels to decrease swelling and congestion[1][2][4].
- Brand names
- DayQuil Cold and FluTylenol Cold Multi-Symptom DaytimeAlka-Seltzer Plus Day ColdTheraflu Daytime Severe Cold & CoughComtrex Cold and CoughVicks DayQuil Cold/FluAlka-Seltzer Plus Day Severe Cold, Cough & FluAlka-Seltzer Plus Day Sinus Congestion, Allergy & CoughAlka-Seltzer Plus Severe Sinus Congestion & Cough
- Other names
- acetaminophen + dextromethorphan + phenylephrine
02
Targets
SIGMAR1 (Sigma non-opioid intracellular receptor 1)COXADRA1A (α1A)NMDAR (Glutamate receptor ionotropic, NMDA)
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