Drug intelligence / Profile preview

acetaminophen + ibuprofen + oxycodone

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination drug containing three active ingredients—acetaminophen, ibuprofen, and oxycodone—used for the management of moderate to severe pain. Acetaminophen is an analgesic and antipyretic that reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that relieves inflammation, swelling, and pain by inhibiting cyclooxygenase (COX) enzymes involved in prostaglandin production. Oxycodone is an opioid analgesic that acts primarily as an agonist at mu-type opioid receptors in the central nervous system to provide potent pain relief. The combination aims to leverage multiple mechanisms of action for enhanced analgesia while potentially reducing individual drug doses and associated side effects[1][2][3][5].

Other names
ibuprofen + acetaminophen + oxycodone-University of Oklahoma-postoperative painibuprofen, acetaminophen, oxycodone
02

Targets

COX-3 (Mitochondrially encoded cytochrome c oxidase subunit 3)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MOR (Mu opioid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)

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