acetaminophen + isometheptene mucate + dichloralphenazone

Replaced original description with the provided description, preserving markdown and escaping double quotes and newlines: "**Acetaminophen + isometheptene mucate + dichloralphenazone** is a combination pharmaceutical product formerly approved and widely used for the acute treatment of tension headaches, vascular headaches, and migraines. It consists of three active ingredients: - **Acetaminophen**: a non-salicylate analgesic and antipyretic that increases the pain threshold, providing general headache relief. - **Isometheptene mucate**: a sympathomimetic amine that causes vasoconstriction of dilated cranial and cerebral blood vessels, reducing vascular headache symptoms. - **Dichloralphenazone**: a sedative that diminishes the emotional response to pain, enhancing overall symptomatic relief. The product was frequently used for acute headache episodes, particularly migraines, but has been discontinued in the US due to regulatory concerns regarding the unapproved status of isometheptene mucate and dichloralphenazone, not for safety or efficacy issues. Some compounded versions may still be available in limited circumstances[1][2][3][4][5][6][7][8]."

Brand names

MidrinAmidrineMigratineNodolorProdrin

Other names

acetaminophen / dichloralphenazone / isometheptene mucateisometheptene-dichloralphenazone-acetaminophenisometheptene mucate, dichloralphenazone and acetaminophen