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acetaminophen + oxycodone ER
- Development stage
- Unknown
- Lead developer
- Mallinckrodt
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Acetaminophen + oxycodone ER is an extended-release fixed-dose combination analgesic tablet developed by Wuhan Humanwell Hi-Tech Industry for the management of moderate to severe pain. This product combines oxycodone, a semi-synthetic opioid agonist that primarily targets mu-opioid receptors in the central nervous system to provide potent analgesia, with acetaminophen, a non-opioid analgesic and antipyretic that provides multimodal pain relief through the inhibition of prostaglandin synthesis. The extended-release formulation is designed to provide sustained plasma concentrations of both active ingredients, allowing for prolonged pain control and a reduction in dosing frequency compared to immediate-release formulations. As of recent reports, a New Drug Application (NDA) has been filed for this product in China.
- Other names
- 氨酚羟考酮缓释片Oxycodone and Acetaminophen Extended-Release Tablet
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)MOR (Mu opioid receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)
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