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acetaminophen + salicylamide + caffeine
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A multi-ingredient, over-the-counter analgesic and antipyretic combination used for the temporary relief of mild to moderate pain (such as headache, muscle aches, dental pain, and fever). It contains three pharmacologically active small molecules: acetaminophen (analgesic and antipyretic), salicylamide (NSAID with analgesic and anti-inflammatory properties), and caffeine (a central nervous system stimulant that enhances the analgesic effect and absorption of acetaminophen and salicylamide). The combination offers broad-spectrum relief by addressing different aspects of pain and is formulated to achieve a synergistic effect, providing greater efficacy than the individual components alone[3][4][5][7][9].
- Brand names
- EXAPRINSaletoCrane Safety XS Pain ReliefGreen Guard Pain and Ache ReliefMedi First Pain ReliefMedi First Plus Pain ZapperAramark Pain FreeUnishield Pain Zapper
- Other names
- acetaminophen/aspirin/caffeine/salicylamideACETAMINOPHEN, ASPIRIN, SALICYLAMIDE and CAFFEINEASPIRIN/CAFFEINE/ACETAMINOPHEN/SALICYLAMIDEPAIN FREECAFFEINE/ACETAMINOPHEN/ASPIRIN/SALICYLAMIDE
02
Targets
ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)ADORA2B (Adenosine A2B receptor)ADORA3 (Adenosine A3 receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ADOR (Adenosine receptors)
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