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Acetate Ringer's solution containing no glucose is an intravenous isotonic fluid used primarily for fluid and electrolyte replacement. It contains sodium acetate as the main buffer instead of lactate, which helps correct metabolic acidosis by being metabolized to bicarbonate in the body. Unlike lactated Ringer’s, it does not contain glucose or dextrose. This makes it suitable for patients or animals where avoiding hyperglycemia is desired. The mechanism of action involves restoring electrolyte balance and expanding plasma volume while correcting acid-base disturbances through metabolism of acetate to bicarbonate. It is commonly used in veterinary medicine (e.g., calves with diarrhea) and human medicine as a balanced crystalloid fluid alternative to normal saline or lactated Ringer’s, especially when liver function may be compromised since acetate metabolism does not rely on the liver as much as lactate.
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