acetazolamide + topiramate

Acetazolamide + topiramate is a pharmacological combination used in the medical management of idiopathic intracranial hypertension (IIH), also known as primary pseudotumor cerebri syndrome. Acetazolamide is a potent carbonic anhydrase inhibitor that reduces the production of cerebrospinal fluid (CSF), thereby lowering intracranial pressure. Topiramate is an anticonvulsant that also possesses carbonic anhydrase inhibitory activity and provides the additional benefit of promoting weight loss, which is a critical modifiable risk factor for IIH. This combination is often evaluated as a conservative management strategy compared to surgical interventions like lumbo-peritoneal shunting. Both agents are well-established generic small-molecule drugs repurposed in combination for this indication.

Other names

acetazolamide and topiramatetopiramate + acetazolamide