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Acetic acid + indigo carmine is a combination diagnostic agent used primarily in endoscopic procedures for enhanced visualization of mucosal lesions, particularly in the gastrointestinal tract. Acetic acid acts as a mucolytic and enhances the contrast of epithelial changes by causing reversible acetowhitening of abnormal epithelium. Indigo carmine is a blue dye that pools in mucosal depressions and highlights surface irregularities. Together, this combination improves detection rates for early neoplastic lesions such as gastric cancer or sessile serrated lesions during chromoendoscopy or chromocolonoscopy[1][2][3]. The mechanism is not therapeutic but diagnostic—improving visual contrast to aid lesion identification.
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