Drug intelligence / Profile preview

acetyl-L-carnitine + alpha-lipoic acid + N-acetyl-L-cysteine

Development stage
Unknown
Lead developer
Vitrolife
Modality
Small Molecules
01

Overview

A3 antioxidant combination is a synergistic formulation of three antioxidants: acetyl-L-carnitine (10 μmol/l), α-lipoic acid (5 μmol/l), and N-acetyl-L-cysteine (10 μmol/l). Developed by the University of Melbourne and commercialized by Vitrolife as part of their Gx Media series (including Gx-MOPS PLUS, Gx-IVF, and Gx-TL), this combination is designed to protect gametes and embryos from oxidative stress during in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) procedures. By mitigating reactive oxygen species (ROS) and supporting mitochondrial function, the A3 combination improves fertilization rates, particularly in ICSI, and increases the number of viable blastocysts available for transfer or cryopreservation.

Brand names
Gx-IVFGx-MOPS PLUSGx-TL
Other names
A3A-3A 3A3 antioxidant combinationA-3 antioxidant combinationA 3 antioxidant combinationA3 antioxidantsA-3 antioxidantsA 3 antioxidantsacetyl-L-carnitine + N-acetyl-L-cysteine + alpha-lipoic acidtriple antioxidant combination
02

Targets

CRAT (Carnitine O-acetyltransferase)PDH (Pyruvate dehydrogenase complex)

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