Acetylcholine + Adenosine

Acetylcholine and adenosine are used in combination as diagnostic pharmacological provocation agents during coronary angiography, specifically within clinical protocols such as the ACOVA trial sponsored by St George's Healthcare NHS Trust. This diagnostic approach is employed to investigate the underlying causes of chest pain in patients with angina pectoris who exhibit angiographically normal or near-normal coronary arteries. Acetylcholine is administered to assess endothelium-dependent vasoreactivity and to provoke coronary artery spasm, which helps identify vasospastic angina. Adenosine is used to induce maximal hyperemia, allowing for the assessment of endothelium-independent microvascular function and the measurement of coronary flow reserve (CFR). Together, these agents help clinicians differentiate between epicardial coronary spasm and coronary microvascular dysfunction.

Other names

ACH + Adenosine