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acetylcysteine + silibinin (VA Office of Research & Development)
- Development stage
- Unknown
- Lead developer
- VA Office of Research & Development
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
N-acetylcysteine + silibinin is an investigational combination of two antioxidant dietary supplements being evaluated for the treatment of diabetic nephropathy in patients with Type 2 Diabetes Mellitus. N-acetylcysteine (NAC) serves as a precursor to glutathione, a major endogenous antioxidant, while silibinin (often administered as the phospholipid complex Siliphos) is a flavonolignan from milk thistle with anti-inflammatory and antioxidant properties. The combination aims to mitigate oxidative stress and inflammatory pathways in the kidney to reduce proteinuria and slow the progression of diabetic kidney disease. It has been studied primarily by the VA Office of Research and Development in Phase 2 clinical trials.
- Other names
- n-acetylcysteine + silibinNAC + silibinNAC + Siliphosacetylcysteine + silibinin
02
Targets
Mucin glycoprotein disulfide bondsGSH (Glutathione)Cyp (Cyclophilin family)LPO (Lactoperoxidase)STAT3 (Signal Transducer and Activator of Transcription 3)
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