Drug intelligence / Profile preview

acetylsalicylic acid + acetaminophen + diclofenac + naproxen

Development stage
Unknown
Lead developer
Novartis
Modality
Small Molecules
Administration
Oral, Topical, Rectal, Intravenous, Intramuscular
01

Overview

This is not a standard combination drug product but rather four separate medications (acetylsalicylic acid, acetaminophen, diclofenac, and naproxen) that are sometimes used in various dual combinations for pain management. Each has different mechanisms of action and safety profiles. * **Acetylsalicylic acid** (aspirin) - A nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase enzymes and preventing platelet aggregation. * **Acetaminophen** (paracetamol) - An analgesic and antipyretic that likely works through central mechanisms by activating descending serotonergic pathways. * **Diclofenac** - A non-selective cyclooxygenase inhibitor NSAID that alters peripheral pain transmission pathways through anti-inflammatory mechanisms. * **Naproxen** - Another NSAID that works by inhibiting cyclooxygenase enzymes.

02

Targets

TRPV1 (Transient receptor potential cation channel subfamily V member 1)CNR1 (Cannabinoid receptor 1)PGHS-1 (Prostaglandin G/H Synthase 1)

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