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acetylsalicylic acid + clopidogrel + ticagrelor
- Development stage
- Phase 2
- Lead developer
- V.A. Almazov Federal Center for Heart, Blood and Endocrinology
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This entry refers to a regimen of antiplatelet agents—acetylsalicylic acid (aspirin), clopidogrel, and ticagrelor—investigated by the Almazov Federal North-West Medical Research Centre for the management of patients undergoing endovascular treatment for intracranial aneurysms. Specifically, the research (such as the DERIVO study) evaluates different combinations and durations of these therapies, including dual antiplatelet therapy (DAPT) consisting of aspirin plus either clopidogrel or ticagrelor, compared against monotherapy. Acetylsalicylic acid acts as a COX-1 inhibitor, while clopidogrel and ticagrelor are P2Y12 receptor antagonists, collectively working to prevent thromboembolic complications associated with flow-diverter stents like the DERIVO device.
- Other names
- ASA + clopidogrel + ticagrelorAspirin + clopidogrel + ticagrelor
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)P2Y12 (Purinergic P2Y12 receptor)
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