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Acetylsalicylic acid + pseudoephedrine

Development stage
Phase 3
Lead developer
Bayer
Modality
Small Molecules
Administration
Oral
01

Overview

Acetylsalicylic acid + pseudoephedrine is a fixed-dose combination of two active pharmaceutical ingredients: acetylsalicylic acid (commonly known as aspirin), a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-inflammatory properties, and pseudoephedrine, an alpha-adrenergic agonist that acts as a nasal decongestant. This combination is used for the symptomatic treatment of pain (such as headache or sore throat), fever, and nasal congestion associated with upper respiratory tract infections like the common cold or flu. Acetylsalicylic acid works by inhibiting cyclooxygenase enzymes COX-1 and COX-2 to reduce prostaglandin synthesis, thereby decreasing inflammation, pain sensitivity, and fever. Pseudoephedrine acts primarily on alpha adrenergic receptors to cause vasoconstriction in the nasal mucosa, reducing swelling and congestion[1][2][5][8]. Developers: Bayer

Brand names
Aspirin ComplexUrsinus
Other names
aspirin and pseudoephedrine
02

Targets

ADRA1 (Alpha-1 adrenergic receptor family)ADRB1 (β1)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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