Drug intelligence / Profile preview

aclidinium bromide + formoterol

Development stage
Approved
Lead developer
Almirall
Modality
Inhalation Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules
Administration
Inhalation
01

Overview

Aclidinium bromide + formoterol is a fixed-dose combination inhalation medication used for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It combines two long-acting bronchodilators from different classes: aclidinium bromide, a long-acting muscarinic antagonist (LAMA/anticholinergic), and formoterol fumarate, a long-acting beta2-adrenergic agonist (LABA). Aclidinium works by inhibiting M3 muscarinic receptors in airway smooth muscle to produce bronchodilation. Formoterol stimulates beta2-adrenergic receptors in the lungs to relax bronchial smooth muscle. The combination provides complementary mechanisms to improve airflow and reduce COPD exacerbations. It is administered as an inhaled dry powder via breath-actuated devices such as Pressair or Genuair[1][3][5].

Brand names
Duaklir PressairBrimica GenuairDuaklir GenuairDuaklir
Other names
aclidinium and formoterolaclidinium/formoterol
02

Targets

CHRM3 (M3)ADRB2 (β2)

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