activated charcoal + polyethylene glycol

This combination therapy consists of activated charcoal and polyethylene glycol (PEG) and is being evaluated by Assistance Publique - Hôpitaux de Paris for the treatment of severe acute poisoning. Activated charcoal is a highly porous adsorbent that binds to various toxic substances within the gastrointestinal tract, preventing their absorption into the systemic circulation. Polyethylene glycol is an osmotic macrogol used for whole bowel irrigation (WBI), which mechanically flushes the gastrointestinal tract to accelerate the elimination of unabsorbed toxins, particularly in cases involving large ingestions of solid-form medications or sustained-release formulations that may form pharmacobezoars. The combination aims to provide a more comprehensive decontamination strategy than standard care in intensive care patients requiring mechanical ventilation.

Other names

Combined digestive decontaminationDIMREATOX