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acyclovir + hydrocortisone
- Development stage
- Approved
- Lead developer
- Medivir
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
**Acyclovir + hydrocortisone** is a fixed-dose topical cream containing 5% acyclovir, an anti-herpesvirus nucleoside analogue, and 1% hydrocortisone, a low-potency corticosteroid. Developed by Medivir as ME-609 and marketed as Xerese, Xerclear, Zoviduo, Zovirax Duo, and Activir Duo, it is used for early treatment of recurrent herpes labialis. Acyclovir is activated preferentially in herpes simplex virus-infected cells and inhibits viral DNA polymerase, while hydrocortisone activates glucocorticoid receptors to suppress local inflammatory responses. The combination reduces the likelihood of progression to ulcerative cold sores and shortens lesion-healing time.
- Brand names
- Activir DuoXerclearXereseZoviduoZovirax Duo
- Other names
- ACHaciclovir + hydrocortisoneaciclovir and hydrocortisoneacyclovir + hydrocortisoneacyclovir and hydrocortisone
02
Targets
GR (Glucocorticoid receptor)HSV DNA pol (Herpes simplex virus DNA polymerase)
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