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adapalene + benzoyl peroxide (Padagis)
- Development stage
- Approved
- Lead developer
- Galderma
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Epiduo-Padagis LLC-acne vulgaris refers to a generic version of the brand-name drug Epiduo, developed and manufactured by Padagis LLC (formerly the generic division of Perrigo). It is a topical combination gel containing 0.1% adapalene, a third-generation retinoid, and 2.5% benzoyl peroxide, an antimicrobial oxidizing agent. Adapalene works by binding to nuclear retinoic acid receptors (specifically RAR-beta and RAR-gamma) to normalize follicular epithelial cell differentiation and reduce comedone formation. Benzoyl peroxide provides bactericidal activity against *Cutibacterium acnes* through the release of free radical oxygen species and exhibits keratolytic properties. This combination therapy is indicated for the topical treatment of acne vulgaris in patients aged 9 years and older.
- Brand names
- Epiduo
- Other names
- Adapalene and Benzoyl Peroxide GelPerrigo Adapalene/BP GelPadagis Adapalene/BP Gel
02
Targets
RARB (Retinoic acid receptor beta)RARA (Retinoic acid receptor alpha)RARG (Retinoic acid receptor gamma)
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