adapalene + benzoyl peroxide + lymecycline

This is a combination therapy for moderate to severe acne vulgaris, consisting of topical adapalene (a third-generation retinoid), topical benzoyl peroxide, and oral lymecycline (a tetracycline-class antibiotic). Adapalene acts as an agonist at retinoic acid receptors, promoting cell turnover and reducing inflammation. Benzoyl peroxide exerts bactericidal effects through free radical generation, targeting *Cutibacterium acnes* and helping keep pores clear. Lymecycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, reducing the population of acne-causing bacteria. The combination targets both inflammatory and non-inflammatory lesions with a synergistic effect that improves efficacy over monotherapy or dual therapy. This regimen is recommended as first-line treatment for moderate to severe acne vulgaris[1][2][5][6][8].

Brand names

Epiduo ForteTetralysal (for lymecycline)Differin (for adapalene)

Other names

A/BPO + lymecyclineadapalene-benzoyl peroxide and oral lymecycline