adapalene + clindamycin + nicotinamide

Adapalene + clindamycin + nicotinamide is a topical combination formulation used primarily for acne vulgaris treatment. Adapalene, a synthetic retinoid, normalizes follicular keratinization, reduces comedone formation, and promotes skin cell turnover; clindamycin, a lincosamide antibiotic, inhibits bacterial protein synthesis to kill Propionibacterium acnes and reduce inflammation; nicotinamide (vitamin B3) provides anti-inflammatory effects, improves skin barrier function, and reduces sebum production. This triple combination addresses multiple acne pathogenesis factors—comedogenesis, bacterial proliferation, and inflammation—for enhanced efficacy over dual adapalene-clindamycin therapies, applied as a gel once daily.

Other names

adapalene + clindamycin