Drug intelligence / Profile preview

adefovir dipivoxil + indinavir

Development stage
Unknown
Lead developer
Gilead Sciences
Modality
Small Molecules
Administration
Oral
01

Overview

This is a **combination of adefovir dipivoxil and indinavir**. **Adefovir dipivoxil** is an oral nucleotide analog prodrug (of adefovir) that inhibits viral DNA polymerase and is primarily used as an antiviral for hepatitis B and investigated for HIV infection. **Indinavir** is a small molecule protease inhibitor targeting HIV-1 protease, inhibiting HIV replication as part of antiretroviral therapy. The **combination has been studied in clinical trials for HIV infection**, particularly in treatment-naive individuals, often along with other nucleoside or nucleotide reverse transcriptase inhibitors. There is no evidence that this combination is a branded, coformulated or widely marketed product; rather, it is a regimen used in combination therapy trials for antiretroviral treatment.

Brand names
Preveon (for adefovir dipivoxil)Crixivan (for indinavir)
Other names
adefovir dipivoxil plus indinavirADV + IDV
02

Targets

HBV Pol (Hepatitis B virus polymerase)Human immunodeficiency virus type 1 reverse transcriptasePOLG (Mitochondrial DNA polymerase gamma)POLA1 (DNA polymerase alpha)PR (Progesterone receptor)

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