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ademetionine + Lactobacillus plantarum HEAL9
- Development stage
- Unknown
- Lead developer
- Hippocrates Research
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Small Molecules, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
SameUp is a food supplement combination developed by Biofarma Group that integrates 200 mg of S-adenosylmethionine (SAMe), also known as ademetionine, with the probiotic strain Lactobacillus plantarum HEAL9 (1 × 10⁹ CFU). The product is designed to manage subthreshold depression and mild-to-moderate depressive symptoms. SAMe serves as a naturally occurring methyl donor in the body, facilitating the synthesis of neurotransmitters and reducing oxidative and nitrosative stress. Lactobacillus plantarum HEAL9 acts as a psychobiotic, influencing the central nervous system through the gut-brain axis. Clinical studies have indicated that this combination provides a rapid onset of action, significantly improving symptoms of depression and anxiety within 2 to 6 weeks, while maintaining a favorable safety profile compared to conventional antidepressants.
- Brand names
- SameUp
- Other names
- s-adenosyl-l-methionine + lactobacillus plantarumSAMe + Lactobacillus plantarum HEAL9SAMe + L. plantarum HEAL9
02
Targets
DNMT (DNA methyltransferase)
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