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adenosine + methacholine
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Inhalation, Intravenous
01
Overview
A combination of adenosine and methacholine used primarily in research and diagnostic settings to study airway responsiveness and asthma. Adenosine is a medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia, while methacholine is a synthetic cholinergic agonist used to diagnose bronchial airway hyperreactivity. When used together, they help investigate the combined effects of different mediators on airway calibre in asthma.
02
Targets
ADORA2A (Adenosine A₂A Receptor)ADORA1 (Adenosine receptor A1 subtype)ADORA2B (Adenosine A2B receptor)CHRM3 (M3)
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