adenosine-2,3-dialdehyde

Adenosine-2,3-dialdehyde, commonly referred to as AdOx, is a potent and irreversible inhibitor of S-adenosylhomocysteine (SAH) hydrolase (adenosylhomocysteinase). By blocking the activity of SAH hydrolase, AdOx prevents the breakdown of SAH into adenosine and homocysteine, leading to a significant intracellular accumulation of SAH. Because SAH is a powerful competitive inhibitor of S-adenosylmethionine (SAM)-dependent methyltransferases, its buildup results in the broad suppression of biological methylation processes, including the methylation of DNA, RNA, and proteins. In biomedical research, AdOx is extensively utilized as a pharmacological tool to study the regulatory roles of methylation in diverse cellular processes such as T-cell activation, viral replication, and epigenetic gene regulation. It is primarily characterized as a research reagent and has not been developed for clinical therapeutic use in humans.

Other names

Periodate-oxidized adenosineAdenosine, 2',3'-dialdehyde2',3'-dialdehyde adenosine