adenosine-5'-[beta, gamma-methylene]tetraphosphate

Adenosine‑5′‑[beta,gamma‑methylene]tetraphosphate is a synthetic nucleotide analog consisting of an adenosine moiety linked to a tetraphosphate chain in which the bridging oxygen between the beta and gamma phosphates is replaced by a methylene group. This modification confers resistance to enzymatic hydrolysis by phosphatases and ATPases. The compound is primarily used as a biochemical tool in research settings to study nucleotide-binding proteins and enzymes that interact with ATP or related nucleotides. It can act as an inhibitor or substrate analog for various kinases and ATP-dependent enzymes due to its structural similarity to natural nucleotides but altered reactivity. There are no known therapeutic indications or clinical uses for this molecule; it is not approved as a pharmaceutical drug.[1][2][4]

Other names

Adenosine-5'-(Beta, Gamma-Methylene)Tetraphosphate(((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)methyl)(hydroxy)phosphoryl)oxy)phosphonic acid{[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan‑2‑yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}methyl)(hydroxy)phosphoryl]oxy}phosphonic acid