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adipose-derived stromal vascular fraction (Assistance publique - Hôpitaux de Paris)
- Development stage
- Unknown
- Lead developer
- Assistance publique - Hôpitaux de Paris
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intramuscular
01
Overview
Adipose-derived stromal vascular fraction (AD-SVF) is an autologous cell therapy consisting of a heterogeneous population of cells extracted from adipose tissue via lipoaspiration and enzymatic digestion. This cellular mixture includes mesenchymal stem cells (ADSCs), endothelial progenitor cells, pericytes, fibroblasts, and various immune cells. In the context of inclusion body myositis (IBM), AD-SVF is investigated for its potential to modulate the chronic inflammatory environment and promote muscle fiber repair through paracrine signaling and direct cellular interactions. The therapy is typically administered via intramuscular injection into affected muscle groups. Assistance Publique - Hôpitaux de Paris (AP-HP) has sponsored clinical trials, such as the MYO-SVF study, to evaluate the safety and preliminary efficacy of this approach in slowing disease progression and improving muscle function in patients with IBM.
- Other names
- AD-SVFSVFstromal vascular fractionautologous adipose-derived stromal vascular fraction
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