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Adipose tissue-derived stromal cells (ADSCs) are a population of multipotent mesenchymal stem cells (MSCs) harvested from adipose tissue, which is a richer source of these cells compared to bone marrow. These cells possess the capacity to differentiate into multiple lineages, including myocardium, vascular endothelial cells, and vascular smooth muscle cells, making them a promising candidate for regenerative medicine. In clinical development by **Kanazawa University**, autologous ADSCs are being investigated for the treatment of **ischemic heart failure**. The therapeutic approach involves the intracoronary administration of these cells via cardiac catheterization to promote heart regeneration and improve cardiac function in patients with a reduced ejection fraction (typically < 40%). The mechanism is thought to involve both direct differentiation into cardiac tissues and the secretion of paracrine factors that stimulate angiogenesis and tissue repair.
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