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adjuvanted swine-origin A (H1N1) pandemic subunit egg-derived vaccine
- Development stage
- Unknown
- Lead developer
- Sanofi
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
This vaccine is an adjuvanted subunit vaccine derived from eggs, designed to provide active immunization against the 2009 pandemic swine-origin Influenza A (H1N1) virus. The vaccine consists of purified, inactivated split virion particles of the H1N1 virus (A/California/7/2009 strain) propagated in embryonated chicken eggs. The addition of an adjuvant (commonly MF59 or AS03, but exact adjuvant not specified for this exact formulation) enhances immunogenicity. The mechanism of action involves induction of strain-specific humoral and cell-mediated immunity primarily targeting the viral hemagglutinin protein, resulting in protection against H1N1 infection. The primary indication is the prevention of pandemic Influenza A (H1N1) in all age groups[4][5].
- Other names
- adjuvanted H1N1 subunit egg-derived vaccineadjuvanted inactivated swine-origin H1N1 pandemic vaccineadjuvanted Influenza A (H1N1) 2009 monovalent vaccine
02
Targets
H1 HA (Influenza A hemagglutinin H1)
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