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Adriamycin + Lomustine + Mercaptopurine + Methotrexate
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Intravenous, Oral, Intramuscular, Intrathecal
01
Overview
This combination involves four chemotherapy drugs: **Adriamycin (Doxorubicin)**, an anthracycline antibiotic that intercalates DNA strands, inhibiting macromolecular biosynthesis; **Lomustine**, a nitrosourea alkylating agent that interferes with DNA and RNA function; **Mercaptopurine (6-Mercaptopurine)**, an antimetabolite that inhibits purine nucleotide synthesis and metabolism; and **Methotrexate**, an antimetabolite that inhibits dihydrofolate reductase, disrupting DNA synthesis and cell replication. This combination is used in cancer treatment, targeting rapidly dividing cells.
02
Targets
DNADHFR (Dihydrofolate reductase)TOP2A (DNA topoisomerase II)
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