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AEG35156 + gemcitabine
- Development stage
- Discontinued
- Lead developer
- Pharmascience
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
AEG35156 + gemcitabine is a drug combination consisting of an **antisense oligonucleotide (AEG35156)** targeting the X-linked inhibitor of apoptosis protein (XIAP) mRNA, and **gemcitabine**, a nucleoside analog antimetabolite used as chemotherapy. AEG35156 reduces XIAP expression, thereby promoting apoptosis and potentially sensitizing cancer cells to chemotherapy. Preclinical studies demonstrated potent activity in pancreatic ductal adenocarcinoma (PDA). In a phase I clinical trial in metastatic PDA, the combination aimed to establish safety, maximum tolerated dose, and preliminary efficacy. The combination did not demonstrate significant antitumor activity in advanced PDA.
02
Targets
DNA polymerase familyRNR (Ribonucleotide reductase)XIAP
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