Drug intelligence / Profile preview

aescin + digitalis glycoside

Development stage
Unknown
Lead developer
Astellas Pharma
Modality
Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous (possible For Some Formulations)
01

Overview

Aescin + digitalis glycoside is a combination drug containing two active components: - **Aescin** (also known as escin) is a natural mixture of saponins derived from the horse chestnut (*Aesculus hippocastanum*), commonly used for its anti-inflammatory, vasoprotective, and anti-edematous properties. It is primarily indicated for chronic venous insufficiency, hemorrhoids, and edema. - **Digitalis glycoside** refers to cardiac glycosides derived from *Digitalis* species (such as digoxin or digitoxin). These compounds are used in the management of heart failure and certain arrhythmias due to their positive inotropic effect on the myocardium. They inhibit sodium-potassium ATPase in cardiac cells, increasing intracellular calcium and thus enhancing cardiac contractility[3][4][5][8]. The combination aims to leverage both the vascular protective effects of aescin and the cardiotonic effects of digitalis glycosides. This may be particularly useful in patients with heart failure or circulatory disorders where both improved venous return and enhanced myocardial function are desired.

Other names
七叶洋地黄双苷
02

Targets

ATP1A (Sodium/potassium-transporting ATPase)

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