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Afatinib + paclitaxel
- Development stage
- Unknown
- Lead developer
- Boehringer Ingelheim
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Afatinib + paclitaxel is a combination therapy used in oncology, particularly for patients with advanced solid tumors and metastatic breast cancer who have failed prior HER2-targeted therapies. Afatinib is an irreversible inhibitor of the ErbB family of tyrosine kinases, including EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4). It blocks intracellular signaling pathways involved in tumor cell proliferation and survival. Paclitaxel is a microtubule-stabilizing agent that inhibits cell division by promoting tubulin polymerization and preventing microtubule disassembly. The combination has demonstrated objective responses in clinical trials, with manageable toxicity profiles. This regimen has been studied for use in metastatic breast cancer, non-small cell lung cancer, and other advanced solid tumors[1][2][3][6][8].
- Brand names
- TaxolAbraxane
- Other names
- BIBW2992BIBW-2992BIBW 2992afatinib dimaleate
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)ABCB1 (P-glycoprotein)ERBB2 (Erb-b2 receptor tyrosine kinase 2)ERBB4 (Erb-b2 receptor tyrosine kinase 4)TUBB (Tubulin (alpha and beta subunits))
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