Drug intelligence / Profile preview

AG + leucovorin + fluorouracil + oxaliplatin + serplulimab + bevacizumab

Development stage
Preclinical
Lead developer
Henlius
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

A combination therapy regimen consisting of AG, leucovorin, fluorouracil (5-FU), oxaliplatin, serplulimab, and bevacizumab. This regimen likely combines traditional chemotherapy agents (fluorouracil, leucovorin, oxaliplatin) with targeted therapy (bevacizumab) and immunotherapy (serplulimab). Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase, while leucovorin enhances its cytotoxic effects. Oxaliplatin is a platinum-based agent that forms DNA adducts. Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF), inhibiting angiogenesis. Serplulimab is likely an immune checkpoint inhibitor targeting PD-1. The AG component is not clearly identified in the available information.

02

Targets

PDCD1 (Programmed cell death protein 1 receptor)VEGFA (Vascular endothelial growth factor A)DNATS (Thymidylate synthase)

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