Drug intelligence / Profile preview

AJU-A51 + A51R3

Development stage
Unknown
Lead developer
AJU Pharm
Modality
Small Molecules
Administration
Oral
01

Overview

AJU-A51 + A51R3 is a fixed-dose combination therapy for type 2 diabetes mellitus, consisting of **dapagliflozin** and **linagliptin** (AJU-A51) plus **A51R3** (likely a related investigational or reference drug used in combination studies). Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, lowering blood glucose by increasing urinary glucose excretion. Linagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor that increases incretin levels, enhancing insulin release and lowering glucagon secretion. This combination is developed for patients with inadequate glycemic control on metformin and DPP-4 inhibitors, demonstrating significant HbA1c reduction and good tolerability in phase 3 trials[1][2][3][4][5][7].

Other names
AJU-A51AJU-A-51AJU-A 51A51R3A-51R3A 51R3
02

Targets

DPP-4 (Dipeptidyl Peptidase-IV)SGLT2 (Sodium-glucose cotransporter protein subunit 2)

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