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AK112 + short-course radiotherapy + capecitabine + oxaliplatin
- Development stage
- Unknown
- Lead developer
- Kangfang Sainuo Pharmaceutical
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
This is a combination therapy regimen consisting of AK112 (a PD-1/VEGF bispecific antibody), short-course radiotherapy (SCRT), and the chemotherapy combination of capecitabine and oxaliplatin (CAPOX). This regimen is being investigated as a neoadjuvant therapy for locally advanced rectal cancer. The treatment protocol typically involves administering short-course radiotherapy followed by AK112 in combination with CAPOX chemotherapy.
- Other names
- AK112 + SCRT + capecitabine + oxaliplatinAK112 + SCRT + CAPOX
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)VEGFA (Vascular endothelial growth factor A)DNATS (Thymidylate synthase)
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