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Al[18F]F-NOTA-folate

Development stage: Unknown
Lead developer: Turku University Hospital
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

Al[18F]F-NOTA-folate is a positron emission tomography (PET) radiopharmaceutical tracer designed to target the folate receptor, specifically the beta isoform (FR-β) expressed on activated macrophages. Developed by researchers at Turku University Hospital, the tracer utilizes an aluminum-fluoride-18 (Al[18F]F) complex chelated by a NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) moiety conjugated to a folate ligand. It is primarily being investigated for the non-invasive detection and monitoring of inflammatory conditions characterized by macrophage infiltration, such as cardiac sarcoidosis and infective endocarditis. By binding to FR-β on activated macrophages rather than relying on metabolic activity (like FDG), it aims to provide higher specificity in imaging myocardial inflammation.

Other names: [18F]AlF-NOTA-folate18F-AlF-NOTA-folateAluminum [18F]fluoride-NOTA-folate

Targets

FOLR1 (FRα)FOLR2 (Folate receptor beta)

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