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Al18F-NOTA-grazytracer + 68Ga-grazytracer

Development stage: Phase 1
Lead developer: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

Al18F-NOTA-grazytracer and 68Ga-grazytracer are investigational PET imaging radiopharmaceuticals designed to target granzyme B, a serine protease released by activated cytotoxic T cells and natural killer cells. Developed by the Cancer Institute and Hospital, Chinese Academy of Medical Sciences, these tracers serve as non-invasive biomarkers for the tumor immune microenvironment. By binding to granzyme B, they allow for the visualization of cytotoxic T-cell activity within tumors, which can help predict treatment response and prognosis in patients with aggressive lymphoma and those undergoing immunotherapy. The two versions utilize different radioisotopes (Fluorine-18 via an AlF-NOTA complex and Gallium-68) to facilitate PET/CT imaging.

Other names: Al18F-NOTA-grazytracer/68Ga-grazytracer

Targets

GZMB (Granzyme B)

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