albendazole + pyrantel pamoate

Albendazole + pyrantel pamoate is a combination anthelmintic medication used to treat various intestinal worm infections including roundworm, hookworm, and pinworm infections. The combination leverages two different mechanisms of action: albendazole inhibits microtubule formation in parasites, while pyrantel pamoate acts as a depolarizing neuromuscular blocking agent that causes spastic paralysis in worms. This combination has been studied particularly for treating Trichuris trichiura (whipworm) infections in school-aged children, though research indicates it may not significantly improve cure rates or egg reduction rates compared to albendazole alone for mild trichuriasis.