Drug intelligence / Profile preview

albumin-bound paclitaxel + cisplatin + tislelizumab

Development stage
Preclinical
Lead developer
BeiGene
Modality
Vaccines & Immunotherapeutics, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
Administration
Intravenous
01

Overview

This is a combination therapy regimen comprising albumin-bound paclitaxel (also known as nab-paclitaxel), cisplatin, and tislelizumab. Albumin-bound paclitaxel is a solvent-free formulation of paclitaxel that utilizes albumin nanoparticle technology to deliver paclitaxel, avoiding the toxicities associated with solvents used in standard paclitaxel formulations. It has been approved for treating metastatic breast cancer, locally advanced or metastatic non-small-cell lung cancer, and metastatic pancreatic cancer. Cisplatin is a chemotherapy agent. Tislelizumab is an anti-PD-1 monoclonal antibody immunotherapy agent. This regimen would represent a combination of chemotherapy (paclitaxel and cisplatin) with immunotherapy (tislelizumab). The provided search results do not contain specific information about the clinical development status, efficacy, or safety profile of this exact three-drug combination.

02

Targets

MicrotubulePDCD1 (Programmed cell death protein 1 receptor)DNA

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