Drug intelligence / Profile preview

Albuterol sulfate HFA (Macleods Pharmaceuticals)

Development stage
Unknown
Lead developer
Macleods Pharmaceuticals
Modality
Small Molecules
Administration
Inhalation
01

Overview

Albuterol sulfate HFA inhalation aerosol, developed by Macleods Pharmaceuticals, is a short-acting beta-2 adrenergic agonist (SABA) bronchodilator. It is indicated for the treatment or prevention of bronchospasm in patients with reversible obstructive airway disease, including asthma and exercise-induced bronchospasm. The drug works by selectively binding to and activating beta-2 adrenergic receptors in the bronchial smooth muscle, which increases cyclic AMP levels and leads to muscle relaxation and airway opening. This formulation is a metered-dose inhaler (MDI) that utilizes hydrofluoroalkane (HFA-134a) as a propellant, delivering 90 mcg of albuterol base per actuation. It was developed as a generic alternative and demonstrated pharmacodynamic bioequivalence to reference albuterol HFA products in clinical trials.

Other names
Albuterol sulfate HFA Inhalation AerosolSalbutamol sulfate HFAMacleods Albuterol HFA
02

Targets

ADRB2 (β2)ADRB1 (β1)

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