Alcaftadine + naphazoline + pheniramine

Alcaftadine + naphazoline + pheniramine is a combination ophthalmic drug intended for the relief of allergic conjunctivitis symptoms, such as eye redness and itching. Alcaftadine is an H1 histamine receptor antagonist that inhibits the release of histamine from mast cells, reducing chemotaxis and eosinophil activation[8]. Naphazoline acts as a vasoconstrictor (decongestant), narrowing swollen blood vessels in the eyes to reduce redness[5][2]. Pheniramine is an antihistamine that blocks H1 receptors, reducing itching and other allergic symptoms by inhibiting histamine action[4][5][2]. This combination targets both vascular congestion and allergic inflammation in the eye.