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alcohol + chlorhexidine digluconate + potassium sorbate

Development stage: Unknown
Lead developer: Centro Ortopédico y Quirúrgico del Pie
Modality: Small Molecules
Administration: Topical

Overview

Alcohol + chlorhexidine digluconate + potassium sorbate is an antiseptic combination solution utilized for surgical hand antisepsis to prevent surgical site infections. The formulation leverages the synergistic effects of its components: alcohol (typically ethanol or isopropanol) provides rapid, broad-spectrum bactericidal activity by denaturing microbial proteins; chlorhexidine digluconate, a cationic biguanide, offers persistent antimicrobial activity by disrupting microbial cell membranes and causing cytoplasmic leakage; and potassium sorbate acts as a preservative and supplemental antimicrobial agent. This specific combination has been evaluated in clinical trials by the Centro Ortopedico y Quirurgico del Pie to determine its effectiveness in reducing bacterial load on the skin of healthcare workers prior to surgery, specifically testing against European standard EN 12791 for surgical hand disinfection.

Brand names: Sorbectol
Other names: alcoholic solution of chlorhexidine digluconate and potassium sorbatealcohol + chlorhexidine + potassium sorbate

Targets

Microbial lipid membranes / membrane proteins by solvent denaturationMicrobial cell membrane phospholipid head groups / anionic cell surface sites

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