alcohol + perampanel

This entry refers to the combination of alcohol (ethanol) and perampanel. Alcohol is a central nervous system depressant commonly consumed as a recreational beverage. Perampanel is an oral antiepileptic drug used primarily for the treatment of partial-onset seizures and primary generalized tonic-clonic seizures. Perampanel acts as a selective, non-competitive antagonist of the AMPA receptor, thereby reducing abnormal neuronal excitation in the brain[3][4][6]. The combination of these two substances is clinically significant because co-administration can increase central nervous system depression and significantly worsen psychiatric side effects such as mood changes and increased anger[1][2][5][8]. Patients taking perampanel are advised to avoid or limit alcohol consumption due to additive or supra-additive impairment in cognition, vigilance, alertness, and increased risk for behavioral adverse reactions.

Brand names

Fycompa

Other names

ethanol2-propanol